Zinc Chelates Bind Human Hemopexin.

Iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock.

The hydroxamic acid siderophore ferrioxamine B [FeIII(HDFB)+] and the iron complex of diethylenetri-aminepentaacetic acid [FeIII(DTPA)2-] protected mice against death by septic shock induced by Corynebacterium parvum + lipopolysaccharide. Although FeIII(DTPA)2- was somewhat more effective than FeIII(HDFB)+, the iron-free ligand H4DFB+ was significantly more effective than DTPA. The hydroxamic a...

A family of human zinc finger proteins that bind methylated DNA and repress transcription.

In vertebrates, densely methylated DNA is associated with inactive transcription. Actors in this process include proteins of the MBD family that can recognize methylated CpGs and repress transcription. Kaiso, a structurally unrelated protein, has also been shown to bind methylated CGCGs through its three Krüppel-like C2H2 zinc fingers. The human genome contains two uncharacterized proteins, ZBT...

Zinc ions bind to and inhibit activated protein C.

Zn2+ ions were found to efficiently inhibit activated protein C (APC), suggesting a potential regulatory function for such inhibition. APC activity assays employing a chromogenic peptide substrate demonstrated that the inhibition was reversible and the apparent K I was 13 +/- 2 microM. k cat was seven fold decreased whereas K M was unaffected in the presence of 10 microM Zn2+. The inhibitory ef...

Dietary effects of zinc, copper and manganese chelates and sulphates on dairy cows

The experiment was carried out on 90 dairy cows in the period from 6 weeks before calving up to 305th day of lactation. The animals randomly divided into 3 groups were fed with diets containing different chemical forms of zinc, manganese and copper applied in mineral mixtures. The control group received these trace elements as sulphates, but in experimental groups 20 or 30% of daily needs were ...

Identification of the Receptor Scavenging Hemopexin- Heme Complexes Running title: Identification of the Hemopexin-Heme Receptor